Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | PRKX | P51817 | 2/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | LTK | P29376 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.45 |
| ▸ | MST1R | Q04912 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14347043 | 0.85 | DDAH1 (0.46) | PLK4MAP4K4PRKXROCK1CLK4 | |
| SCHEMBL31363694 | 0.81 | PARP1 (0.44) | PLK4MAP4K4PRKXROCK1CLK4 | |
| SCHEMBL7002080 | 0.81 | KDM4E (0.48) | KDM4EMAPK1HSD17B10LMNARAB9A | |
| SCHEMBL7363561 | 0.81 | PLK4 (0.42) | PLK4MAP4K4PRKXROCK1CLK4 | |
| SCHEMBL1933250 | 0.81 | PLK4 (0.50) | PLK4MAP4K4PRKXROCK1CLK4 | |
| SCHEMBL1683119 | 0.79 | PARP1 (0.46) | PARP1 | |
| SCHEMBL7145208 | 0.78 | BCHE (0.38) | KDM4ERECQLHSD17B10RAB9ASMN1; SMN2 | |
| SCHEMBL871830 | 0.76 | PARP1 (0.58) | PLK4MAP4K4PRKXROCK1CLK4 | |
| SCHEMBL7362374 | 0.76 | PARP1 (0.40) | PLK4MAP4K4PRKXROCK1CLK4 | |
| SCHEMBL6841122 | 0.76 | PARP1 (0.61) | PLK4MAP4K4PRKXROCK1CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003106430-A1 | BENZIMIDAZOLE INHIBITORS OF POLY(ADP-RIBOSYL) POLYMERASE | PFIZER INC. (US) | 2003-12-24 | — | — | WO | disclosed |