Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.52 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1760529 | 0.78 | CA1 (0.70) | GABRA1GABRB1GABRB2CA1CA2 | |
| SCHEMBL4907457 | 0.78 | GABRA1 (0.50) | GABRA1GABRB1GABRB2CA1CA2 | |
| SCHEMBL20816450 | 0.76 | GABRA1 (0.50) | GABRA1GABRB1GABRB2CA1CA2 | |
| SCHEMBL3435343 | 0.76 | CA1 (0.46) | GABRA1GABRB1GABRB2CA1CA2 | |
| SCHEMBL4714238 | 0.74 | GABRA1 (0.52) | GABRA1GABRB1GABRB2CA1CA2 | |
| SCHEMBL4715891 | 0.74 | CA1 (0.44) | GABRA1GABRB1GABRB2CA1CA2 | |
| SCHEMBL6282235 | 0.74 | CA1 (0.44) | GABRA1GABRB1GABRB2CA1CA2 | |
| SCHEMBL21251576 | 0.74 | CA1 (0.44) | GABRA1GABRB1GABRB2CA1CA2 | |
| SCHEMBL4712954 | 0.74 | GABRA1 (0.52) | GABRA1GABRB1GABRB2CA1CA2 | |
| SCHEMBL10951011 | 0.74 | CA1 (0.44) | GABRA1GABRB1GABRB2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160095823-A1 | METHODS OF USING PROPOFOL DERIVATIVES FOR ANALGESIA | THE UNIVERSITY OF LIVERPOOL (GB) | 2016-04-07 | — | — | US | claimed |
| US-20070142477-A1 | ANALGESIA | THE UNIVERSITY OF LIVERPOOL (GB) | 2007-06-21 | — | — | US | claimed |
| EP-1965780-B1 | Propofol derivatives as analgesics | UNIV LIVERPOOL (GB) | 2017-03-08 | — | — | EP | disclosed |
| US-20160095823-A1 | METHODS OF USING PROPOFOL DERIVATIVES FOR ANALGESIA | THE UNIVERSITY OF LIVERPOOL (GB) | 2016-04-07 | — | — | US | disclosed |
| EP-1965780-A2 | SUBSTITUTED PHENOL DERIVATIVES AS ANALGESICS | THE UNIVERSITY OF LIVERPOOL (GB) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007071967-A2 | SUBSTITUTED PHENOL DERIVATIVES AS ANALGESICS | THE UNIVERSITY OF LIVERPOOL (GB) | 2007-06-28 | — | — | WO | disclosed |
| US-20070142477-A1 | ANALGESIA | THE UNIVERSITY OF LIVERPOOL (GB) | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160095823-A1 | METHODS OF USING PROPOFOL DERIVATIVES FOR ANALGESIA | GRIN3A, OPRL1, GRIK5 | GABRA1 9/4885GABRB1 29/4885GABRB2 27/4885 |
| US-20070142477-A1 | ANALGESIA | GRIN3A, OPRL1, GABRA5 | GABRA1 6/4885GABRB1 32/4885GABRB2 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.