Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4713692 | 0.77 | TAAR1 (0.44) | TP53TAAR1ALDH1A1HPGDPOLB | |
| SCHEMBL2468335 | 0.77 | ALDH1A1 (0.56) | TAAR1ALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL3316301 | 0.77 | KDM4E (0.44) | EPHX2ALDH1A1HPGDKMT2AKDM4E | |
| SCHEMBL4715540 | 0.76 | NPC1 (0.45) | TAAR1ALDH1A1LMNAPOLBKMT2A | |
| Formic Acid SCHEMBL5082583 | 0.75 | ALDH1A1 (0.49) | TP53TAAR1ALDH1A1HPGDLMNA | |
| SCHEMBL4711078 | 0.75 | L3MBTL1 (0.42) | MAPTTAAR1EPHX2ALDH1A1LMNA | |
| SCHEMBL3317179 | 0.72 | NPC1 (0.61) | ALDH1A1HPGDPOLBKMT2ACHRM1 | |
| SCHEMBL10348018 | 0.72 | ALDH1A1 (0.54) | TP53MAPTTHRBTAAR1ALDH1A1 | |
| SCHEMBL29101911 | 0.71 | TAAR1 (0.44) | TAAR1HPGDNPC1 | |
| SCHEMBL4713876 | 0.71 | TLR2 (0.50) | TAAR1ALDH1A1KMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933830-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | Vernalis (R&D) Limited (GB) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007007057-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | VERNALIS (R & D) LIMITED (GB) | 2007-01-18 | — | — | WO | disclosed |