Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 10/20 | 0.63 |
| ▸ | GRM5 | P41594 | 6/20 | 0.58 |
| ▸ | MGLL | Q99685 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4712675 | 0.84 | HSD11B1 (0.60) | HSD11B1MGLLKDM4EPOLBGAA | |
| SCHEMBL4715310 | 0.83 | HSD11B1 (0.56) | HSD11B1 | |
| SCHEMBL4710380 | 0.75 | GRM5 (0.64) | GRM5 | |
| SCHEMBL6236172 | 0.74 | HSD11B1 (1.00) | HSD11B1MGLLKDM4EPOLBGAA | |
| SCHEMBL6356849 | 0.73 | HSD11B1 (0.69) | HSD11B1MGLLKDM4EPOLBGAA | |
| SCHEMBL22874837 | 0.73 | GRM5 (1.00) | GRM5 | |
| SCHEMBL3640225 | 0.73 | GRM5 (0.74) | HSD11B1GRM5MGLL | |
| SCHEMBL6209453 | 0.73 | SLC18A3 (0.75) | HSD11B1MGLLKDM4EPOLBGAA | |
| SCHEMBL6210205 | 0.73 | HSD11B1 (0.65) | HSD11B1MGLLKDM4EPOLBGAA | |
| SCHEMBL19917537 | 0.73 | HSD11B1 (0.66) | HSD11B1MGLLKDM4EPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | claimed |
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |