Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.45 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4717579 | 0.87 | AGTR1 (0.44) | AGTR1NR4A3HCAR3 | |
| SCHEMBL27737816 | 0.85 | NR4A3 (0.51) | AGTR1NR4A3HCAR3 | |
| SCHEMBL31053372 | 0.79 | NR4A3 (0.43) | NR4A3 | |
| SCHEMBL4716984 | 0.77 | AGTR1 (0.42) | AGTR1NR4A3HCAR3 | |
| SCHEMBL4719726 | 0.77 | LMNA (0.43) | — | |
| SCHEMBL4716749 | 0.76 | AGTR1 (0.41) | AGTR1NR4A3HCAR3 | |
| SCHEMBL28036519 | 0.76 | MAPK14 (0.46) | AGTR1 | |
| SCHEMBL13126531 | 0.74 | KMT2A (0.36) | — | |
| SCHEMBL369444 | 0.73 | NPBWR1 (0.48) | — | |
| SCHEMBL4719231 | 0.72 | POLB (0.48) | AGTR1NR4A3HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101405270-B | Pyrazoles as 11-beta-HSD-1 | HOFFMANN LA ROCHE | 2013-01-16 | — | — | CN | claimed |
| CN-101405270-A | Pyrazoles as 11-beta-HSD-1 | HOFFMANN LA ROCHE (CH) | 2009-04-08 | — | — | CN | claimed |
| CN-101405270-B | Pyrazoles as 11-beta-HSD-1 | HOFFMANN LA ROCHE | 2013-01-16 | — | — | CN | disclosed |
| CN-101405270-A | Pyrazoles as 11-beta-HSD-1 | HOFFMANN LA ROCHE (CH) | 2009-04-08 | — | — | CN | disclosed |
| EP-1999114-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. Hoffmann-la Roche AG (CH) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007107470-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | WO | disclosed |