Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31674277 | 0.85 | FFAR4 (0.36) | CES2CES1RIPK1FFAR4FFAR1 | |
| SCHEMBL23782854 | 0.84 | FFAR4 (0.35) | FFAR4FFAR1CHRNA7 | |
| SCHEMBL4322411 | 0.83 | CES2 (0.42) | CES2CES1RIPK1FFAR4 | |
| SCHEMBL4717045 | 0.82 | FFAR1 (0.49) | CES2CES1RIPK1FFAR4FFAR1 | |
| SCHEMBL30572329 | 0.81 | MPO (0.46) | CES2CES1RIPK1FFAR4FFAR1 | |
| SCHEMBL5419671 | 0.80 | CES2 (0.43) | CES2CES1RIPK1CA2P2RX7 | |
| SCHEMBL4718220 | 0.78 | CES2 (0.38) | CES2CES1FFAR4FFAR1 | |
| SCHEMBL29009960 | 0.77 | HDAC3 (0.47) | CES2CES1RIPK1FFAR4FFAR1 | |
| Methyl Alcohol SCHEMBL3621979 | 0.77 | RIPK1 (0.43) | CES2CES1RIPK1CA2P2RX7 | |
| SCHEMBL1477462 | 0.76 | PSEN1 (0.42) | CES2CES1RIPK1FFAR4FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337517-B1 | PYRIMIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 2008-11-26 | — | — | EP | disclosed |
| EP-1337517-A1 | PYRIMIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 2003-08-27 | — | — | EP | disclosed |
| WO-2002030911-A1 | PYRIMIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-04-18 | — | — | WO | disclosed |