Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.61 |
| ▸ | S1PR1 | P21453 | 10/20 | 0.56 |
| ▸ | S1PR3 | Q99500 | 10/20 | 0.56 |
| ▸ | S1PR2 | O95136 | 8/20 | 0.56 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.56 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.56 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3457044 | 0.83 | HRH3 (0.51) | HRH4HRH3SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL4713979 | 0.81 | SMN1; SMN2 (0.53) | HRH4HRH3SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL3457092 | 0.81 | CHRM2 (0.51) | HRH4HRH3S1PR1KCNH2SMN1; SMN2 | |
| SCHEMBL4717200 | 0.80 | CYP1A2 (0.53) | HRH4HRH3CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL4420094 | 0.80 | USP2 (0.60) | HRH4HRH3KCNH2SMN1; SMN2LMNA | |
| SCHEMBL17898131 | 0.79 | HRH4 (0.76) | HRH4HRH3S1PR1S1PR3S1PR2 | |
| SCHEMBL3456657 | 0.78 | L3MBTL1 (0.51) | HRH4HRH3SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL5765031 | 0.78 | S1PR2 (0.53) | S1PR1S1PR3S1PR2LPAR2CYP1A2 | |
| SCHEMBL4717560 | 0.78 | GAA (0.48) | HRH4HRH3SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL19217017 | 0.77 | S1PR1 (0.73) | HRH4HRH3S1PR1S1PR3S1PR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462620-B2 | Pyrimidinone derivatives and their use in the treatment of atherosclerosis | SMITHKLINE BEECHAM, PLC (GB) | 2008-12-09 | — | — | US | disclosed |
| US-7462620-B2 | Pyrimidinone derivatives and their use in the treatment of atherosclerosis | SMITHKLINE BEECHAM, PLC (GB) | 2008-12-09 | — | — | US | disclosed |
| EP-1337517-B1 | PYRIMIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 2008-11-26 | — | — | EP | disclosed |
| US-7169924-B2 | Pyrimidinone derivatives and their use in the treatment of atherosclerosis | SMITHKLINE BEECHAM PLC (GB) | 2007-01-30 | — | — | US | disclosed |
| US-7169924-B2 | Pyrimidinone derivatives and their use in the treatment of atherosclerosis | SMITHKLINE BEECHAM PLC (GB) | 2007-01-30 | — | — | US | disclosed |
| US-20060241126-A1 | Pyrimidinone Derivatives and Their Use in the Treatment of Atherosclerosis | ELLIOTT RICHARD L | 2006-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241126-A1 | Pyrimidinone Derivatives and Their Use in the Treatment of Atherosclerosis | PLA2G7, PLA2G1B, PLA2G4B | HRH4 1494/4885HRH3 1720/4885S1PR1 148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.