Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.41 |
| ▸ | RGS4 | P49798 | 1/20 | 0.41 |
| ▸ | RGS8 | P57771 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5119050 | 0.81 | CCR2 (0.62) | MAPTMAPK8MAPK9CCR2ERCC5 | |
| SCHEMBL4715213 | 0.79 | CCR2 (0.51) | MAPTMAPK8MAPK9CCR2ALDH1A1 | |
| SCHEMBL4717102 | 0.78 | MAPK8 (0.46) | MAPTMAPK8MAPK9CCR2PGR | |
| SCHEMBL4717022 | 0.77 | CCR2 (0.49) | MAPTMAPK8MAPK9CCR2ALDH1A1 | |
| SCHEMBL4711188 | 0.77 | BRD4 (0.53) | MAPTMAPK8MAPK9CCR2ALDH1A1 | |
| SCHEMBL4715185 | 0.76 | BRD4 (0.48) | MAPTMAPK8MAPK9CCR2ALDH1A1 | |
| SCHEMBL4712174 | 0.75 | MAPT (0.51) | MAPTCCR2ALDH1A1LMNAKMT2A | |
| SCHEMBL4712460 | 0.75 | PTGS2 (0.51) | MAPTCCR2ALDH1A1LMNAKMT2A | |
| SCHEMBL4714910 | 0.74 | CCR2 (0.46) | MAPTMAPK8MAPK9CCR2ALDH1A1 | |
| SCHEMBL4716315 | 0.73 | ALDH1A1 (0.47) | MAPTEGLN1MAPK8MAPK9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549648-B1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS KINASE INHIBITORS | UCB PHARMA SA (BE) | 2008-11-12 | — | — | EP | disclosed |