Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4472813 | 0.86 | HPGD (0.51) | HPGDTDP1CYP3A4HSP90AA1HSP90AB1 | |
| SCHEMBL3552169 | 0.85 | USP2 (0.52) | HPGDCYP3A4HSP90AA1HSP90AB1MAPT | |
| SCHEMBL509845 | 0.82 | HPGD (0.58) | HPGDTDP1HSP90AA1HSP90AB1MAPT | |
| SCHEMBL16305344 | 0.81 | CHRM2 (0.56) | HPGDTDP1CYP3A4HSP90AA1HSP90AB1 | |
| SCHEMBL3555893 | 0.81 | CYP3A4 (0.49) | HPGDCYP3A4HSP90AA1HSP90AB1MAPT | |
| SCHEMBL10213485 | 0.80 | ALDH1A1 (0.56) | HPGDCYP3A4HSP90AA1MAPTRAB9A | |
| SCHEMBL471668 | 0.79 | HPGD (0.51) | HPGDTDP1HSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL4462445 | 0.79 | CYP3A4 (0.50) | HPGDCYP3A4HSP90AA1HSP90AB1MAPT | |
| SCHEMBL29956454 | 0.79 | CYP3A4 (0.47) | HPGDTDP1CYP3A4HSP90AA1HSP90AB1 | |
| SCHEMBL4037887 | 0.79 | CYP3A4 (0.47) | HPGDTDP1CYP3A4HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572805-B2 | Pyrrolo(oxo)isoquinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-11 | — | — | US | disclosed |
| US-20060014777-A1 | Pyrrolo(oxo)isoquinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY | 2006-01-19 | — | — | US | disclosed |
| US-5122608-A | Hydrolysis ofa 2,3-pyridine- or quinolinedicarboxylic acid diester with water and a acid having an ionization constant of 3; treating with a base and separating | AMERICAN CYANAMID COMPANY (US) | 1992-06-16 | — | — | US | disclosed |
| EP-0133310-B1 | IMIDAZOLIDINONES, AND IMIDAZOLIDINETHIONES, PROCESS FOR THE PREPARATION THEREOF, AND USE OF SAID COMPOUNDS AS HERBICIDAL AGENTS | AMERICAN CYANAMID COMPANY (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4608079-A | Imidazolidinones, and imidazolidinethiones, process and intermediates for the preparation thereof, and use of said compounds as herbicidal agents | AMERICAN CYANAMID COMPANY (US) | 1986-08-26 | — | — | US | disclosed |
| US-4554013-A | Herbicidal imidazolinyl naphthoic acids | AMERICAN CYANAMID COMPANY (US) | 1985-11-19 | — | — | US | disclosed |
| EP-0133311-A2 | Substituted imidazolinyl benzoic acids, esters and salts and use thereof as herbicidal agents | AMERICAN CYANAMID COMPANY (US) | 1985-02-20 | — | — | EP | disclosed |
| EP-0133310-A1 | Imidazolidinones, and imidazolidinethiones, process for the preparation thereof, and use of said compounds as herbicidal agents | AMERICAN CYANAMID COMPANY (US) | 1985-02-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014777-A1 | Pyrrolo(oxo)isoquinolines as 5HT ligands | HTR2B, OPRD1, HTR1B | HPGD 2536/4885TDP1 3311/4885CYP3A4 1738/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.