Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 4/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.41 |
| ▸ | RXRB | P28702 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11870778 | 0.80 | SLC6A4 (0.46) | HTR1ASLC6A2SLC6A4SLC6A3BRD4 | |
| SCHEMBL9015265 | 0.79 | CHRNA7 (0.44) | MAPK1HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22368749 | 0.77 | BRD4 (0.61) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL8878028 | 0.76 | SRC (0.42) | HTR2CSRC | |
| SCHEMBL4716831 | 0.76 | MAPT (0.50) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL31443854 | 0.76 | MAPT (0.50) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL29144623 | 0.76 | HTR2A (0.49) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL30702565 | 0.76 | HTR2A (0.49) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL4138667 | 0.76 | BRD4 (0.56) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL4718545 | 0.76 | SRC (0.44) | HTR1ASLC6A2SLC6A4SLC6A3LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101309904-A | 1- (1H-indol-1-yl) -3- (methylamino) -1-phenylpropan-2-ol derivatives and related compounds as monoamine reuptake modulators for the treatment of vasomotor symptoms (VMS) | WYETH CORP (US) | 2008-11-19 | — | — | CN | disclosed |
| EP-1931631-A1 | 1- (1H- INDOL- 1-YL) -3- (METHYLAMINO) -1- PHENYLPROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) | Wyeth a Corporation of the State of Delaware (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007041023-A1 | 1- (1H- INDOL- 1-YL) -3- (METHYLAMINO) -1- PHENYLPROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) | WYETH (US) | 2007-04-12 | — | — | WO | disclosed |
| US-20070072897-A1 | Phenylaminopropanol derivatives and methods of their use | WYETH (US) | 2007-03-29 | — | — | US | disclosed |
| US-6509476-B1 | Leukotriene antagonists; antiallergens, antiinflammatory agents, and antiasthmatic agents | THE UNIVERSITY OF EAST ANGLIA (GB) | 2003-01-21 | — | — | US | disclosed |
| US-6160120-A | Process for preparing n-benzyl indoles | ELI LILLY AND COMPANY (US) | 2000-12-12 | — | — | US | disclosed |
| US-5807866-A | Process for preparing N-benzyl indoles | THE UNIVERSITY OF EAST ANGLIA (GB) | 1998-09-15 | — | — | US | disclosed |
| EP-0775694-A2 | Process for preparing N-benzyl indoles | University of East Anglia (GB) | 1997-05-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072897-A1 | Phenylaminopropanol derivatives and methods of their use | COMT, PNMT, GLS | MAPT 1848/4885MAPK1 1355/4885TDP1 418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.