Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 8/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.50 |
| ▸ | PPARG | P37231 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3788790 | 0.79 | ALDH1A1 (0.66) | CYP1A2CYP2C9HPGDCYP3A4CYP2D6 | |
| SCHEMBL28091035 | 0.79 | GPR27 (0.57) | GPR27CYP1A2CYP2C9HPGDCYP3A4 | |
| SCHEMBL4155586 | 0.78 | JAK2 (0.73) | GPR27HPGDMAPTMEN1KMT2A | |
| SCHEMBL31171411 | 0.77 | XPO1 (0.54) | GPR27GAACYP1A2CYP2C9CYP3A4 | |
| SCHEMBL10455617 | 0.77 | TMPRSS4 (0.64) | GPR27CYP1A2CYP2C9HPGDCYP3A4 | |
| SCHEMBL31710075 | 0.76 | MEN1 (0.53) | GPR27GAAHPGDMEN1KMT2A | |
| SCHEMBL1203522 | 0.75 | SMO (0.80) | CYP1A2HPGDMAPTCYP2C19MEN1 | |
| SCHEMBL1648370 | 0.75 | GPR27 (0.53) | GPR27CYP1A2CYP2C9HPGDCYP3A4 | |
| SCHEMBL107955 | 0.75 | TSHR (0.52) | CYP1A2HPGDMAPTLMNATP53 | |
| Water SCHEMBL27602058 | 0.74 | SMO (0.77) | CYP1A2HPGDMAPTCYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957073-A2 | MEDICINAL DRUG | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007066784-A2 | DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-06-14 | — | — | WO | disclosed |