Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 12/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4716488 | 0.85 | CD274 (0.50) | BDKRB1NAMPTF10CHRM4CD274 | |
| SCHEMBL4712468 | 0.80 | HRH3 (0.51) | BDKRB1NAMPT | |
| SCHEMBL4713068 | 0.73 | BDKRB1 (0.47) | BDKRB1NAMPTF10 | |
| SCHEMBL4714985 | 0.73 | BDKRB1 (0.51) | BDKRB1F10CHRM4 | |
| SCHEMBL4715173 | 0.71 | BDKRB1 (0.69) | BDKRB1F10 | |
| SCHEMBL4718806 | 0.71 | BDKRB1 (0.52) | BDKRB1CHRM2CHRM4 | |
| SCHEMBL5842753 | 0.70 | BDKRB1 (0.51) | BDKRB1CHRM2F10CHRM4 | |
| SCHEMBL4714121 | 0.70 | BDKRB1 (0.70) | BDKRB1F10 | |
| SCHEMBL4790805 | 0.70 | VCP (0.54) | BDKRB1 | |
| SCHEMBL4717342 | 0.70 | ACHE (0.50) | NAMPTF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877401-A2 | NOVEL COMPOUNDS USEFUL FOR BRADYKININ B1 RECEPTOR ANTAGONISM | Elan Pharmaceuticals Inc. (US) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006113140-A2 | NOVEL COMPOUNDS USEFUL FOR BRADYKININ B1 RECEPTOR ANTAGONISM | ELAN PHARMACEUTICALS, INC. (US) | 2006-10-26 | — | — | WO | disclosed |