Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | SPPL2A | Q8TCT8 | 6/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.36 |
| ▸ | PARG | Q86W56 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4717707 | 1.00 | RXFP1 (0.40) | RXFP1SPPL2APSEN1PSEN2APH1B | |
| Butyric Acid SCHEMBL4155430 | 0.91 | KDM4E (0.37) | RXFP1SPPL2APSEN1PSEN2APH1B | |
| Butyric Acid SCHEMBL4166269 | 0.91 | KDM4E (0.37) | RXFP1SPPL2APSEN1PSEN2APH1B | |
| SCHEMBL4716505 | 0.84 | RXFP1 (0.38) | RXFP1PARGKDM4ETP53HSD17B10 | |
| SCHEMBL4714851 | 0.81 | CA2 (0.35) | RXFP1PARGKDM4ETP53BRD4 | |
| SCHEMBL4715853 | 0.81 | CA2 (0.35) | RXFP1PARGKDM4ETP53BRD4 | |
| SCHEMBL4717207 | 0.81 | MAPT (0.47) | RXFP1PARGKDM4EBRD4HSD17B10 | |
| SCHEMBL3249112 | 0.81 | MAPT (0.38) | RXFP1SPPL2APSEN1PSEN2APH1B | |
| SCHEMBL3251302 | 0.81 | MAPT (0.38) | RXFP1SPPL2APSEN1PSEN2APH1B | |
| SCHEMBL3249109 | 0.81 | MAPT (0.38) | RXFP1SPPL2APSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | claimed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | claimed |