Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PARG | Q86W56 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | PARP1 | P09874 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyric Acid SCHEMBL4155236 | 0.92 | MAPT (0.36) | RXFP1MAPTLMNATP53SLC6A2 | |
| SCHEMBL4717705 | 0.84 | RXFP1 (0.40) | RXFP1PARGMAPTPARP1TP53 | |
| SCHEMBL4717707 | 0.84 | RXFP1 (0.40) | RXFP1PARGMAPTPARP1TP53 | |
| SCHEMBL3244680 | 0.82 | MAPT (0.42) | TDP1MAPTLMNATP53KDM4E | |
| SCHEMBL4713618 | 0.81 | RXFP1 (0.41) | RXFP1MAPTPARP1LMNATP53 | |
| Butyric Acid SCHEMBL4155243 | 0.79 | KDM4E (0.39) | RXFP1PARGMAPTLMNATP53 | |
| SCHEMBL4717207 | 0.79 | MAPT (0.47) | RXFP1PARGMAPTLMNASLC6A2 | |
| SCHEMBL4716487 | 0.79 | RXFP1 (0.36) | RXFP1PARGMAPTKDM4EHSD17B10 | |
| Propionic Acid SCHEMBL4159470 | 0.78 | ALDH1A1 (0.38) | RXFP1MAPTLMNATP53SLC6A2 | |
| Hydrochloric Acid SCHEMBL4155231 | 0.78 | MAPT (0.35) | MAPTPARP1LMNATP53SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | claimed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | claimed |