Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4721077 | 0.91 | PARP1 (0.37) | ALDH1A1GAALMNAKDM4EHSD17B10 | |
| SCHEMBL4718967 | 0.89 | KDM4E (0.39) | ALDH1A1GAALMNAKDM4EHSD17B10 | |
| SCHEMBL4719631 | 0.89 | ALDH1A1 (0.36) | ALDH1A1GAALMNAKDM4EHSD17B10 | |
| SCHEMBL27614310 | 0.88 | PARP1 (0.38) | LMNAMAPTHPGDKMT2APARP1 | |
| SCHEMBL291018 | 0.84 | ALDH1A1 (0.44) | ALDH1A1GAALMNAKDM4EHSD17B10 | |
| SCHEMBL29831878 | 0.84 | ALDH1A1 (0.44) | ALDH1A1GAALMNAKDM4EHSD17B10 | |
| SCHEMBL4718179 | 0.84 | NPC1 (0.41) | ALDH1A1GAALMNAKDM4EHSD17B10 | |
| SCHEMBL4718237 | 0.83 | PDE4A (0.40) | ALDH1A1GAALMNAKDM4EPDE4B | |
| SCHEMBL4542766 | 0.78 | NOTUM (0.41) | LMNAPDE4BMAPTPDE4APDE4C | |
| SCHEMBL29831842 | 0.77 | HPGD (0.42) | ALDH1A1GAALMNAKDM4EPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458722-B1 | PYRROLOPYRIMIDINES AS PHOSPHODIESTERASE VII INHIBITORS | MERCK PATENT GMBH (DE) | 2008-10-15 | — | — | EP | claimed |
| EP-1458722-B1 | PYRROLOPYRIMIDINES AS PHOSPHODIESTERASE VII INHIBITORS | MERCK PATENT GMBH (DE) | 2008-10-15 | — | — | EP | disclosed |