Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | BCAT2 | O15382 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4717818 | 0.91 | ALDH1A1 (0.39) | PARP1HPGDMAPTLMNAKMT2A | |
| SCHEMBL27614310 | 0.90 | PARP1 (0.38) | PARP1HPGDBCAT2MAPTBLM | |
| SCHEMBL4718150 | 0.86 | MAPT (0.43) | HPGDBCAT2MAPTBLMLMNA | |
| SCHEMBL29831842 | 0.84 | HPGD (0.42) | PARP1HPGDBCAT2MAPTBLM | |
| SCHEMBL290194 | 0.84 | HPGD (0.42) | PARP1HPGDBCAT2MAPTBLM | |
| SCHEMBL4542766 | 0.80 | NOTUM (0.41) | PARP1HPGDBCAT2MAPTBLM | |
| SCHEMBL4720475 | 0.80 | BCAT2 (0.42) | HPGDBCAT2MAPTBLMLMNA | |
| SCHEMBL4719631 | 0.79 | ALDH1A1 (0.36) | PARP1HPGDMAPTLMNAKMT2A | |
| SCHEMBL4718967 | 0.79 | KDM4E (0.39) | PARP1HPGDMAPTLMNAKMT2A | |
| SCHEMBL291018 | 0.78 | ALDH1A1 (0.44) | HPGDMAPTLMNAKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458722-B1 | PYRROLOPYRIMIDINES AS PHOSPHODIESTERASE VII INHIBITORS | MERCK PATENT GMBH (DE) | 2008-10-15 | — | — | EP | claimed |
| EP-1458722-B1 | PYRROLOPYRIMIDINES AS PHOSPHODIESTERASE VII INHIBITORS | MERCK PATENT GMBH (DE) | 2008-10-15 | — | — | EP | disclosed |