Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718179 | 0.89 | NPC1 (0.41) | HTTALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL29831915 | 0.84 | LMNA (0.46) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL2680052 | 0.84 | LMNA (0.46) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL4717818 | 0.83 | ALDH1A1 (0.39) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL4718967 | 0.80 | KDM4E (0.39) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL4721414 | 0.78 | MAPT (0.46) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL4721077 | 0.73 | PARP1 (0.37) | HTTALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL4717738 | 0.73 | MAPT (0.39) | HTTALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL4719631 | 0.72 | ALDH1A1 (0.36) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL290505 | 0.72 | KDM4E (0.48) | HTTALDH1A1LMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458722-B1 | PYRROLOPYRIMIDINES AS PHOSPHODIESTERASE VII INHIBITORS | MERCK PATENT GMBH (DE) | 2008-10-15 | — | — | EP | claimed |
| EP-1458722-B1 | PYRROLOPYRIMIDINES AS PHOSPHODIESTERASE VII INHIBITORS | MERCK PATENT GMBH (DE) | 2008-10-15 | — | — | EP | disclosed |