Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | SHMT1 | P34896 | 6/20 | 0.38 |
| ▸ | SHMT2 | P34897 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | EIF4E | P06730 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1339515 | 0.85 | GFER (0.43) | GFERSHMT1SHMT2KDM4ETDP1 | |
| SCHEMBL1338957 | 0.84 | GFER (0.44) | GFERSHMT1SHMT2KDM4ETDP1 | |
| SCHEMBL1339448 | 0.77 | SHMT1 (0.38) | SHMT1SHMT2KDM4EL3MBTL1LMNA | |
| SCHEMBL1336852 | 0.76 | SHMT1 (0.38) | GFERSHMT1SHMT2KDM4EALDH1A1 | |
| SCHEMBL1338217 | 0.76 | SHMT1 (0.40) | SHMT1SHMT2KDM4EL3MBTL1LMNA | |
| SCHEMBL1338195 | 0.75 | SHMT1 (0.37) | SHMT1SHMT2KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL1339424 | 0.75 | SHMT1 (0.47) | SHMT1SHMT2KDM4EALDH1A1LMNA | |
| SCHEMBL1338262 | 0.73 | ENPP2 (0.46) | — | |
| SCHEMBL1338722 | 0.73 | GABRA1 (0.42) | SHMT1SHMT2KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL1339227 | 0.72 | GABRA1 (0.41) | KDM4EALDH1A1EIF4ERAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940840-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007045758-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-04-26 | — | — | WO | disclosed |