Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1406858 | 0.95 | PDE4B (0.48) | PDE4BPDE4DPKMKDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL4718722 | 0.93 | PDE4B (0.47) | PDE4BPDE4DPKMKDM4EHSD17B10 | |
| SCHEMBL1407037 | 0.87 | LMNA (0.47) | PDE4BKDM4EHSD17B10LMNASMN1; SMN2 | |
| SCHEMBL1406557 | 0.87 | NR3C1 (0.43) | PDE4D | |
| SCHEMBL1406792 | 0.84 | LMNA (0.51) | PDE4BKDM4ELMNASMN1; SMN2MAPT | |
| SCHEMBL1407209 | 0.84 | LMNA (0.48) | PDE4BKDM4EHSD17B10LMNASMN1; SMN2 | |
| SCHEMBL1406968 | 0.83 | LMNA (0.53) | PDE4BLMNAMAPT | |
| SCHEMBL17097772 | 0.82 | HSD11B1 (0.45) | KDM4EHSD17B10LMNASMN1; SMN2 | |
| SCHEMBL17097774 | 0.82 | HSD11B1 (0.45) | KDM4EHSD17B10LMNASMN1; SMN2 | |
| SCHEMBL1407122 | 0.82 | LMNA (0.44) | KDM4EHSD17B10LMNASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999114-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. Hoffmann-la Roche AG (CH) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007107470-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | WO | disclosed |