Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.44 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.43 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.42 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Emidurdar SCHEMBL30845296 | 0.92 | KCNMA1 (0.54) | GPR35KCNMA1GRIK1MAPTRAB9A | |
| Emidurdar SCHEMBL1463101 | 0.92 | KCNMA1 (0.54) | GPR35KCNMA1GRIK1MAPTRAB9A | |
| SCHEMBL1463507 | 0.90 | KMT2A (0.45) | GRIK1MAPTKMT2ARAB9AMEN1 | |
| SCHEMBL1462393 | 0.89 | GRIK1 (0.60) | GPR35KCNMA1GRIK1MAPTKMT2A | |
| SCHEMBL1463403 | 0.86 | KDR (0.45) | GRIK1MAPTKMT2ARAB9AMEN1 | |
| SCHEMBL1463473 | 0.86 | KMT2A (0.46) | GPR35MAPTKMT2ARAB9AMEN1 | |
| SCHEMBL3577164 | 0.85 | GRIK1 (0.46) | GPR35GRIK1MTORBAZ1A | |
| SCHEMBL1463337 | 0.85 | KDR (0.54) | MAPTKMT2AMEN1HTTTRPV1 | |
| SCHEMBL3576165 | 0.84 | GRIK1 (0.48) | EPHX2GRIK1MAPTCA12CA1 | |
| SCHEMBL1462366 | 0.83 | ALDH1A1 (0.46) | KCNMA1GRIK1KMT2ARAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663192-B1 | hERG1 CHANNEL OPENERS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | NEUROSEARCH AS (DK) | 2008-12-03 | — | — | EP | claimed |
| CN-1845726-A | Erg channel openers for the treatment of cardiac arrhythmias | POSEIDON PHARMACEUTICALS AS (DK) | 2006-10-11 | — | — | CN | disclosed |