Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 10/20 | 0.69 |
| ▸ | MMP10 | P09238 | 4/20 | 0.56 |
| ▸ | MMP8 | P22894 | 4/20 | 0.56 |
| ▸ | MMP9 | P14780 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719607 | 0.84 | MMP13 (0.72) | MMP13MMP10MMP8MMP9POLB | |
| SCHEMBL29838134 | 0.83 | MMP13 (1.00) | MMP13MMP10MMP8MMP9POLB | |
| SCHEMBL8358823 | 0.83 | MMP13 (1.00) | MMP13MMP10MMP8MMP9POLB | |
| SCHEMBL8357428 | 0.81 | MMP13 (0.90) | MMP13MMP10MMP8MMP9POLB | |
| SCHEMBL6474462 | 0.81 | MMP13 (0.79) | MMP13MMP10MMP8MMP9POLB | |
| SCHEMBL8331676 | 0.81 | MMP13 (0.72) | MMP13MMP10MMP8MMP9POLB | |
| SCHEMBL8360162 | 0.80 | MMP13 (0.88) | MMP13MMP10MMP8MMP9ALDH1A1 | |
| SCHEMBL14602306 | 0.80 | MMP13 (0.75) | MMP13MMP10MMP8MMP9POLB | |
| SCHEMBL12272887 | 0.80 | MMP13 (0.92) | MMP13MMP10MMP8MMP9L3MBTL1 | |
| SCHEMBL5615854 | 0.79 | MMP13 (0.86) | MMP13MMP10MMP8MMP9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560815-B1 | NOVEL PYRIMIDINE-4,6-DICARBOXAMIDES FOR THE SELECTIVE INHIBITION OF COLLAGENASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2008-03-12 | — | — | EP | claimed |