Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 8/20 | 0.72 |
| ▸ | MMP10 | P09238 | 3/20 | 0.56 |
| ▸ | MMP8 | P22894 | 3/20 | 0.56 |
| ▸ | MMP9 | P14780 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14602306 | 0.90 | MMP13 (0.75) | MMP13MMP10MMP8MMP9LMNA | |
| SCHEMBL6474462 | 0.87 | MMP13 (0.79) | MMP13MMP10MMP8MMP9GAA | |
| SCHEMBL29838134 | 0.83 | MMP13 (1.00) | MMP13MMP10MMP8MMP9L3MBTL1 | |
| SCHEMBL8358823 | 0.83 | MMP13 (1.00) | MMP13MMP10MMP8MMP9L3MBTL1 | |
| SCHEMBL4720963 | 0.83 | MMP13 (0.72) | MMP13MMP10MMP8MMP9GAA | |
| SCHEMBL8357428 | 0.81 | MMP13 (0.90) | MMP13MMP10MMP8MMP9GAA | |
| SCHEMBL4718422 | 0.81 | MMP13 (0.69) | MMP13MMP10MMP8MMP9LMNA | |
| SCHEMBL8360162 | 0.80 | MMP13 (0.88) | MMP13MMP10MMP8MMP9ALDH1A1 | |
| SCHEMBL12272887 | 0.80 | MMP13 (0.92) | MMP13MMP10MMP8MMP9L3MBTL1 | |
| SCHEMBL14468713 | 0.80 | MMP13 (0.78) | MMP13MMP10MMP8MMP9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166609-B2 | Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-01-23 | — | — | US | disclosed |
| US-7166609-B2 | Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-01-23 | — | — | US | disclosed |
| WO-2004041788-A1 | NOVEL PYRIMIDINE-4,6-DICARBOXAMIDES FOR THE SELECTIVE INHIBITION OF COLLAGENASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-05-21 | — | — | WO | disclosed |