Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 10/20 | 0.79 |
| ▸ | MMP10 | P09238 | 4/20 | 0.64 |
| ▸ | MMP8 | P22894 | 4/20 | 0.64 |
| ▸ | MMP9 | P14780 | 1/20 | 0.64 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358823 | 0.88 | MMP13 (1.00) | MMP13MMP10MMP8MMP9POLB | |
| SCHEMBL29838134 | 0.88 | MMP13 (1.00) | MMP13MMP10MMP8MMP9POLB | |
| SCHEMBL8331676 | 0.87 | MMP13 (0.72) | MMP13MMP10MMP8MMP9ALDH1A1 | |
| SCHEMBL4720963 | 0.87 | MMP13 (0.72) | MMP13MMP10MMP8MMP9GAA | |
| SCHEMBL5615671 | 0.87 | MMP13 (0.84) | MMP13MMP10MMP8MMP9EPHX2 | |
| SCHEMBL8360162 | 0.87 | MMP13 (0.88) | MMP13MMP10MMP8MMP9ALDH1A1 | |
| SCHEMBL8357428 | 0.85 | MMP13 (0.90) | MMP13MMP10MMP8MMP9ALDH1A1 | |
| SCHEMBL4716566 | 0.85 | MMP13 (0.90) | MMP13MMP10MMP8MMP9NR1H4 | |
| SCHEMBL5615610 | 0.85 | MMP13 (0.77) | MMP13MMP10MMP8MMP9EPHX2 | |
| SCHEMBL15647278 | 0.84 | MMP13 (0.86) | MMP13MMP10MMP8MMP9EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004111-A1 | Degenerative joints disease; osteoarthritis | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004111-A1 | Degenerative joints disease; osteoarthritis | MMP13, ADAMTS13, DPYD | MMP13 1/4885MMP10 13/4885MMP8 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.