Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 11/20 | 0.81 |
| ▸ | PTGS2 | P35354 | 12/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718829 | 0.89 | PTGS1 (1.00) | PTGS1PTGS2KDM4EUSP2ALDH1A1 | |
| SCHEMBL4718168 | 0.89 | PTGS1 (0.83) | PTGS1PTGS2KDM4EUSP2ALDH1A1 | |
| SCHEMBL4721120 | 0.89 | PTGS1 (0.83) | PTGS1PTGS2KDM4EUSP2ALDH1A1 | |
| SCHEMBL4722523 | 0.85 | PTGS1 (0.76) | PTGS1PTGS2KDM4EUSP2ALDH1A1 | |
| SCHEMBL4722456 | 0.80 | PTGS1 (0.68) | PTGS1PTGS2KDM4EUSP2ALDH1A1 | |
| SCHEMBL6408442 | 0.79 | PTGS1 (0.67) | PTGS1PTGS2KDM4ETP53HPGD | |
| SCHEMBL4504052 | 0.78 | PTGS1 (1.00) | PTGS1PTGS2KDM4EUSP2ALDH1A1 | |
| SCHEMBL4720953 | 0.76 | PTGS1 (0.48) | PTGS1PTGS2 | |
| SCHEMBL4721292 | 0.74 | SDHB (0.81) | PTGS1PTGS2KDM4EUSP2ALDH1A1 | |
| SCHEMBL4720369 | 0.74 | PTGS1 (1.00) | PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1493735-B1 | PYRIMIDINE DERIVATIVES USEFUL AS SELECTIVE COX-2 INHIBITORS | GLAXO GROUP LTD (GB) | 2008-10-29 | — | — | EP | claimed |