Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.39 |
| ▸ | ACACB | O00763 | 6/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | GPR6 | P46095 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL390647 | 0.89 | GPR119 (0.70) | GPR119CYP2C9 | |
| SCHEMBL3169459 | 0.88 | GPR119 (0.55) | GPR119CYP2C9ACACB | |
| SCHEMBL4719031 | 0.85 | GPR119 (0.59) | GPR119CYP2C9RAF1MAPK3ACACB | |
| SCHEMBL4718453 | 0.83 | GPR119 (0.79) | GPR119CYP2C9 | |
| SCHEMBL4722977 | 0.82 | GPR119 (0.55) | GPR119CYP2C9ACACBCHRM4GPR6 | |
| SCHEMBL3170510 | 0.79 | GPR119 (0.57) | GPR119CYP2C9 | |
| SCHEMBL386781 | 0.76 | GPR119 (0.70) | GPR119CYP2C9 | |
| SCHEMBL4719808 | 0.76 | GPR119 (0.49) | GPR119CYP2C9ACACB | |
| SCHEMBL4722061 | 0.76 | GPR119 (0.51) | GPR119TBK1ACACB | |
| SCHEMBL4721373 | 0.76 | GPR119 (0.57) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |