Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 2/20 | 0.40 |
| ▸ | GPR6 | P46095 | 1/20 | 0.39 |
| ▸ | DCK | P27707 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL389562 | 0.87 | GPR119 (0.71) | GPR119CYP2C9 | |
| SCHEMBL4719031 | 0.86 | GPR119 (0.59) | GPR119CHRM4CHRM2CHRM5CHRM1 | |
| SCHEMBL4723322 | 0.85 | GPR119 (0.45) | GPR119CHRM4ACACBGPR6 | |
| SCHEMBL4721373 | 0.84 | GPR119 (0.57) | GPR119 | |
| SCHEMBL4718453 | 0.84 | GPR119 (0.79) | GPR119CYP2C9 | |
| SCHEMBL4719083 | 0.84 | GPR119 (0.56) | GPR119CYP2C9ACACBGPR6 | |
| SCHEMBL4718845 | 0.83 | GPR119 (0.63) | GPR119CYP2C9ACACB | |
| SCHEMBL4718680 | 0.82 | GPR119 (0.55) | GPR119CHRM4CHRM2CHRM5CHRM1 | |
| SCHEMBL4719808 | 0.81 | GPR119 (0.49) | GPR119CYP2C9ACACB | |
| SCHEMBL3161673 | 0.80 | GPR119 (0.62) | GPR119CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |