Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 8/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4721685 | 0.92 | CHRM4 (0.38) | CHRM4CHRM2CHRM5CHRM1CHRM3 | |
| SCHEMBL388956 | 0.88 | GPR119 (0.46) | CHRM4GPR119TBK1 | |
| SCHEMBL4721775 | 0.87 | GPR119 (0.39) | CHRM4CHRM2CHRM5CHRM1CHRM3 | |
| SCHEMBL4763290 | 0.84 | TBK1 (0.40) | HTR2CSLC6A4HTR2AACACBGPR119 | |
| SCHEMBL27769070 | 0.83 | CHRM4 (0.43) | CHRM4CHRM2CHRM5CHRM1CHRM3 | |
| SCHEMBL4719875 | 0.83 | MKNK1 (0.39) | HTR2CSLC6A4HTR2AACACBGPR119 | |
| SCHEMBL4721984 | 0.82 | HTR2C (0.40) | HTR2CSLC6A4HTR2AACACBGPR119 | |
| SCHEMBL391299 | 0.80 | GPR119 (0.46) | CHRM4CHRM2CHRM5CHRM1CHRM3 | |
| SCHEMBL4719039 | 0.80 | GPR119 (0.34) | CHRM4CHRM2CHRM5CHRM1CHRM3 | |
| SCHEMBL4719868 | 0.80 | SSTR4 (0.35) | ACACBGPR119TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |