Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 5/20 | 0.35 |
| ▸ | SSTR1 | P30872 | 4/20 | 0.35 |
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | DCK | P27707 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4721685 | 0.91 | CHRM4 (0.38) | GPR119MAP2K7SSTR4SSTR1ACACB | |
| SCHEMBL389866 | 0.88 | GPR119 (0.46) | GPR119TBK1 | |
| SCHEMBL4718792 | 0.87 | CHRM4 (0.38) | GPR119ACACBCHRM4TBK1CHRM2 | |
| SCHEMBL4719132 | 0.84 | LCK (0.36) | GPR119SSTR4SSTR1ACACBTBK1 | |
| SCHEMBL391299 | 0.79 | GPR119 (0.46) | GPR119CHRM4TBK1CHRM2CHRM5 | |
| SCHEMBL4723214 | 0.79 | ERBB2 (0.39) | TBK1 | |
| SCHEMBL4719868 | 0.78 | SSTR4 (0.35) | GPR119SSTR4SSTR1ACACBTBK1 | |
| SCHEMBL4718652 | 0.76 | TBK1 (0.39) | GPR119ACACBTBK1 | |
| SCHEMBL4723287 | 0.75 | TBK1 (0.39) | GPR119ACACBTBK1S1PR1 | |
| SCHEMBL4722459 | 0.75 | TBK1 (0.38) | GPR119ACACBTBK1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |