Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 3/20 | 0.45 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 3/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718240 | 0.85 | CENPE (0.47) | CENPEKIFC1TOP2ATAS1R3TAS1R1 | |
| SCHEMBL4718275 | 0.84 | CENPE (0.47) | CENPEKIFC1TOP2ATAS1R3TAS1R1 | |
| SCHEMBL4718279 | 0.81 | CENPE (0.46) | CENPEKIFC1TOP2ATAS1R3TAS1R1 | |
| SCHEMBL4718406 | 0.80 | CENPE (0.39) | CENPETOP2ATAS1R3TAS1R1FOXO1 | |
| SCHEMBL4838720 | 0.80 | CENPE (0.62) | CENPES1PR1S1PR3S1PR5 | |
| SCHEMBL3233577 | 0.79 | CENPE (0.52) | CENPEKIFC1TAS1R3TAS1R1S1PR1 | |
| SCHEMBL4762148 | 0.79 | CENPE (0.52) | CENPEKIFC1TAS1R3TAS1R1S1PR1 | |
| SCHEMBL4720739 | 0.78 | CENPE (0.45) | CENPEKIFC1TOP2ATAS1R3TAS1R1 | |
| SCHEMBL4835978 | 0.78 | CENPE (0.44) | CENPEKIFC1TOP2ATAS1R3TAS1R1 | |
| SCHEMBL13644414 | 0.76 | CENPE (0.47) | CENPEKIFC1TOP2ATAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | claimed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | claimed |
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |