Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 2/20 | 0.36 |
| ▸ | GCGR | P47871 | 2/20 | 0.35 |
| ▸ | GIPR | P48546 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 7/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4717681 | 0.91 | CENPE (0.36) | CENPEGCGRGIPRPPARGTAS1R3 | |
| SCHEMBL4718241 | 0.87 | CENPE (0.39) | CENPEGCGRGIPRPPARGTAS1R3 | |
| SCHEMBL4899980 | 0.81 | CENPE (0.47) | CENPETAS1R3TAS1R1 | |
| SCHEMBL4718281 | 0.81 | CENPE (0.36) | CENPEGCGRGIPRPPARGTAS1R3 | |
| SCHEMBL3233585 | 0.79 | CENPE (0.41) | CENPEGCGRGIPRPPARGTAS1R3 | |
| SCHEMBL2617238 | 0.74 | TAS1R3 (0.43) | CENPEGCGRGIPRPPARGTAS1R3 | |
| SCHEMBL4722601 | 0.73 | GCGR (0.43) | GCGRGIPRPPARGTAS1R3TAS1R1 | |
| SCHEMBL13637058 | 0.72 | TAS1R3 (0.43) | CENPEPPARGTAS1R3TAS1R1POLB | |
| SCHEMBL13584837 | 0.72 | CENPE (0.47) | CENPETAS1R3TAS1R1 | |
| SCHEMBL13584838 | 0.72 | CENPE (0.47) | CENPETAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | claimed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | claimed |
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |