Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 2/20 | 0.43 |
| ▸ | GIPR | P48546 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 10/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718876 | 0.73 | CENPE (0.36) | GCGRGIPRPPARGKDM1AHDAC1 | |
| SCHEMBL2617238 | 0.72 | TAS1R3 (0.43) | GCGRGIPRPPARGTAS1R3TAS1R1 | |
| SCHEMBL4717681 | 0.71 | CENPE (0.36) | GCGRGIPRPPARGKDM1AHDAC1 | |
| SCHEMBL4718281 | 0.70 | CENPE (0.36) | GCGRGIPRPPARGTAS1R3TAS1R1 | |
| SCHEMBL4718241 | 0.70 | CENPE (0.39) | GCGRGIPRPPARGTAS1R3TAS1R1 | |
| SCHEMBL4838728 | 0.70 | CENPE (0.45) | — | |
| SCHEMBL4767596 | 0.67 | CENPE (0.44) | TAS1R3TAS1R1NPC1 | |
| SCHEMBL13184025 | 0.67 | CENPE (0.40) | PPARG | |
| SCHEMBL13707933 | 0.66 | CENPE (0.59) | NPC1 | |
| SCHEMBL4776899 | 0.66 | MEN1 (0.37) | GCGRGIPRPPARGCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |