Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.35 |
| ▸ | ITGAL | P20701 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 4/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718873 | 1.00 | P2RX7 (0.35) | P2RX7PDE3BPDE3APDE7AITGB2 | |
| SCHEMBL4722458 | 0.93 | ABL1 (0.39) | P2RX7PDE3BPDE3APDE7AITGB2 | |
| SCHEMBL4722453 | 0.93 | ABL1 (0.39) | P2RX7PDE3BPDE3APDE7AITGB2 | |
| SCHEMBL4724504 | 0.90 | ITGB2 (0.38) | P2RX7PDE3BPDE3APDE7AITGB2 | |
| SCHEMBL4724501 | 0.90 | ITGB2 (0.38) | P2RX7PDE3BPDE3APDE7AITGB2 | |
| SCHEMBL4719571 | 0.89 | PDE7A (0.38) | P2RX7PDE3BPDE3APDE7AITGB2 | |
| SCHEMBL4719565 | 0.89 | PDE7A (0.38) | P2RX7PDE3BPDE3APDE7AITGB2 | |
| SCHEMBL4723310 | 0.88 | ITGB2 (0.40) | ITGB2ICAM1ITGAL | |
| SCHEMBL4723315 | 0.88 | ITGB2 (0.40) | ITGB2ICAM1ITGAL | |
| SCHEMBL4722822 | 0.88 | F2 (0.37) | F10F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |