Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 2/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.38 |
| ▸ | ITGAL | P20701 | 2/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.35 |
| ▸ | SMPD3 | Q9NY59 | 3/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | GAK | O14976 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | INSRR | P14616 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4724501 | 1.00 | ITGB2 (0.38) | ITGB2ICAM1ITGALPDE7AMCHR1 | |
| SCHEMBL4765817 | 0.90 | P2RX7 (0.38) | RORCPDE3BPDE3AP2RX7NOTUM | |
| SCHEMBL4765812 | 0.90 | P2RX7 (0.38) | RORCPDE3BPDE3AP2RX7NOTUM | |
| SCHEMBL4718873 | 0.90 | P2RX7 (0.35) | ITGB2ICAM1ITGALPDE7ARORC | |
| SCHEMBL4718877 | 0.90 | P2RX7 (0.35) | ITGB2ICAM1ITGALPDE7ARORC | |
| SCHEMBL14102050 | 0.89 | PDE10A (0.37) | ROCK2NOTUMMAPTMAPK1 | |
| SCHEMBL4722458 | 0.85 | ABL1 (0.39) | ITGB2ICAM1ITGALPDE7ARORC | |
| SCHEMBL4722453 | 0.85 | ABL1 (0.39) | ITGB2ICAM1ITGALPDE7ARORC | |
| SCHEMBL4723372 | 0.84 | PDE4A (0.43) | ITGB2ICAM1ITGALPDE7AMCHR1 | |
| SCHEMBL4723378 | 0.84 | PDE4A (0.43) | ITGB2ICAM1ITGALPDE7AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |