Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 6/20 | 0.60 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.60 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.60 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.60 |
| ▸ | TMPRSS6 | Q8IU80 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | PLAU | P00749 | 2/20 | 0.50 |
| ▸ | MASP2 | O00187 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 2/20 | 0.46 |
| ▸ | F12 | P00748 | 1/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718976 | 0.82 | CA2 (0.67) | F2PRSS1PRSS3PRSS2TMPRSS6 | |
| SCHEMBL7106023 | 0.80 | F2 (0.58) | F2PRSS1PRSS3PRSS2TMPRSS6 | |
| SCHEMBL1818606 | 0.80 | PRSS1 (0.58) | F2PRSS1PRSS3PRSS2TMPRSS6 | |
| SCHEMBL423771 | 0.80 | F2 (0.58) | F2PRSS1PRSS3PRSS2TMPRSS6 | |
| Hydrochloric Acid SCHEMBL4176794 | 0.78 | PRSS1 (0.56) | F2PRSS1PRSS3PRSS2TMPRSS6 | |
| SCHEMBL8127463 | 0.78 | CYP2D6 (0.55) | F2PRSS1PRSS3PRSS2TMPRSS6 | |
| SCHEMBL537030 | 0.77 | LMNA (0.77) | F2PRSS1PRSS3PRSS2TMPRSS6 | |
| SCHEMBL8173731 | 0.77 | PRSS1 (0.55) | F2PRSS1PRSS3PRSS2TMPRSS6 | |
| SCHEMBL14448891 | 0.75 | TMPRSS6 (0.60) | F2PRSS1PRSS3PRSS2TMPRSS6 | |
| SCHEMBL17803155 | 0.75 | F2 (0.53) | F2PRSS1PRSS3PRSS2TMPRSS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216230-B1 | FUSED CYCLOHEPTANE AND FUSED AZACYCLOHEPTANE COMPOUNDS AND THEIR USE AS INTEGRIN RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2008-04-23 | — | — | EP | disclosed |