Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 6/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 3/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3732394 | 0.90 | FAAH (0.41) | NAMPTKCNQ3KCNQ2CHRM1HTR2A | |
| SCHEMBL4709225 | 0.89 | NAMPT (0.43) | NAMPTRAB9ACHRM1HTR2AMCHR1 | |
| SCHEMBL3728465 | 0.88 | MEN1 (0.43) | NAMPTKCNQ3KCNQ2CHRM1HTR2A | |
| SCHEMBL3735920 | 0.87 | TBK1 (0.45) | NAMPTFAAHMAPTEPHX2 | |
| SCHEMBL3733024 | 0.87 | NAMPT (0.47) | NAMPTKCNQ3KCNQ2TRPV1 | |
| SCHEMBL3738335 | 0.87 | PIK3CA (0.47) | NAMPTTRPV1 | |
| SCHEMBL3733287 | 0.87 | FAAH (0.41) | NAMPTKCNQ3KCNQ2CHRM1HTR2A | |
| SCHEMBL3742347 | 0.87 | FAAH (0.41) | NAMPTKCNQ3KCNQ2GALR3RAB9A | |
| SCHEMBL3744319 | 0.86 | ALDH1A1 (0.47) | NAMPTFAAH | |
| SCHEMBL3742331 | 0.84 | NAMPT (0.45) | NAMPTKCNQ3KCNQ2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959947-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007075377-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |