Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 3/20 | 0.38 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 8/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 6/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3223147 | 0.83 | CENPE (0.43) | CENPEKIFC1S1PR1MAP4K4MINK1 | |
| SCHEMBL4722508 | 0.82 | CENPE (0.45) | CENPEKIFC1S1PR1TOP2AMAP4K4 | |
| SCHEMBL4717550 | 0.79 | CENPE (0.45) | CENPEKIFC1S1PR1MAP4K4MINK1 | |
| SCHEMBL4718279 | 0.72 | CENPE (0.46) | CENPEKIFC1S1PR1TOP2AMAP4K4 | |
| SCHEMBL3226744 | 0.72 | CENPE (0.53) | CENPEKIFC1S1PR1MAP4K4MINK1 | |
| SCHEMBL4720522 | 0.70 | CENPE (0.43) | CENPEKIFC1S1PR1TOP2AMAP4K4 | |
| SCHEMBL4835978 | 0.70 | CENPE (0.44) | CENPEKIFC1S1PR1TOP2A | |
| SCHEMBL13161748 | 0.69 | CENPE (0.48) | CENPEKIFC1S1PR1MAP4K4MINK1 | |
| SCHEMBL2101580 | 0.69 | CENPE (0.48) | CENPEKIFC1S1PR1MAP4K4MINK1 | |
| SCHEMBL4717914 | 0.68 | CENPE (0.42) | CENPEKIFC1S1PR1TOP2AMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | claimed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | claimed |