Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 4/20 | 0.51 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.48 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719430 | 0.89 | PTGDR2 (0.59) | BAZ2BAKR1B10AKR1B1PTGDR2HDAC1 | |
| SCHEMBL4719539 | 0.88 | PTGDR2 (0.58) | BAZ2BPTGDR2 | |
| SCHEMBL4721545 | 0.88 | BAZ2B (0.64) | BAZ2BAKR1B10AKR1B1PTGDR2HDAC1 | |
| SCHEMBL3085456 | 0.85 | KRAS (0.67) | KRASBAZ2BAKR1B10AKR1B1PTGDR2 | |
| SCHEMBL4721439 | 0.83 | PTGDR2 (0.59) | BAZ2BAKR1B10AKR1B1PTGDR2HDAC1 | |
| SCHEMBL4722882 | 0.82 | BAZ2B (0.53) | BAZ2BAKR1B10AKR1B1PTGDR2AKR1A1 | |
| SCHEMBL4718940 | 0.77 | PTGDR2 (0.60) | BAZ2BPTGDR2HDAC1HDAC6 | |
| SCHEMBL3083804 | 0.74 | PTGDR2 (0.68) | KRASBAZ2BAKR1B10AKR1B1PTGDR2 | |
| SCHEMBL5026847 | 0.73 | TSPO (0.39) | KRAS | |
| SCHEMBL3096312 | 0.73 | PTGDR2 (0.77) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725553-B1 | TETRAHYDROPYRIDOINDOLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-05-07 | — | — | EP | claimed |