Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 2/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.33 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27951655 | 0.93 | TBK1 (0.38) | TBK1MKNK1MKNK2ACACBGPR119 | |
| SCHEMBL4722068 | 0.91 | TBK1 (0.37) | TBK1ACACBGPR119NAMPT | |
| SCHEMBL386386 | 0.89 | TBK1 (0.48) | TBK1GPR119SLC2A1GRIN2B | |
| SCHEMBL4718846 | 0.86 | GPR119 (0.35) | TBK1ACACBGPR119S1PR1 | |
| SCHEMBL4723045 | 0.84 | CYP1A2 (0.44) | TBK1NAMPT | |
| SCHEMBL27939028 | 0.83 | ALDH1A1 (0.37) | TBK1 | |
| SCHEMBL4719868 | 0.81 | SSTR4 (0.35) | TBK1ACACBGPR119 | |
| SCHEMBL4719132 | 0.81 | LCK (0.36) | TBK1ACACBGPR119 | |
| SCHEMBL4721758 | 0.80 | PDE5A (0.39) | — | |
| SCHEMBL4718690 | 0.80 | TBK1 (0.38) | TBK1ACACBGPR119S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |