Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.32 |
| ▸ | TYK2 | P29597 | 3/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4723705 | 0.87 | TRPV1 (0.30) | — | |
| SCHEMBL4722506 | 0.86 | RIOK2 (0.34) | — | |
| SCHEMBL4719259 | 0.86 | L3MBTL1 (0.33) | JAK2TYK2JAK1 | |
| SCHEMBL4722717 | 0.83 | MAPT (0.42) | JAK2TYK2JAK1 | |
| SCHEMBL4722289 | 0.83 | IMPDH2 (0.36) | — | |
| SCHEMBL4721138 | 0.81 | JAK2 (0.34) | JAK2TYK2JAK1 | |
| SCHEMBL4721053 | 0.81 | — | — | |
| SCHEMBL4722942 | 0.81 | MEN1 (0.31) | JAK2TYK2JAK1 | |
| SCHEMBL4721371 | 0.81 | PTK2 (0.33) | JAK2TYK2JAK1 | |
| SCHEMBL4724241 | 0.81 | F10 (0.35) | JAK2TYK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |