Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 8/20 | 0.72 |
| ▸ | MMP10 | P09238 | 3/20 | 0.56 |
| ▸ | MMP8 | P22894 | 3/20 | 0.56 |
| ▸ | MMP9 | P14780 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718797 | 0.88 | MMP13 (0.75) | MMP13MMP10MMP8MMP9 | |
| SCHEMBL6474462 | 0.87 | MMP13 (0.79) | MMP13MMP10MMP8MMP9GAA | |
| SCHEMBL8358823 | 0.83 | MMP13 (1.00) | MMP13MMP10MMP8MMP9 | |
| SCHEMBL29838134 | 0.83 | MMP13 (1.00) | MMP13MMP10MMP8MMP9 | |
| SCHEMBL8331676 | 0.83 | MMP13 (0.72) | MMP13MMP10MMP8MMP9GAA | |
| SCHEMBL8357428 | 0.81 | MMP13 (0.90) | MMP13MMP10MMP8MMP9GAA | |
| SCHEMBL8335069 | 0.81 | MMP13 (0.77) | MMP13MMP10MMP8MMP9MAPT | |
| SCHEMBL8360162 | 0.80 | MMP13 (0.88) | MMP13MMP10MMP8MMP9HTT | |
| SCHEMBL12272887 | 0.80 | MMP13 (0.92) | MMP13MMP10MMP8MMP9NPC1 | |
| SCHEMBL5615854 | 0.79 | MMP13 (0.86) | MMP13MMP10MMP8MMP9GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560815-B1 | NOVEL PYRIMIDINE-4,6-DICARBOXAMIDES FOR THE SELECTIVE INHIBITION OF COLLAGENASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2008-03-12 | — | — | EP | claimed |
| US-7166609-B2 | Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-01-23 | — | — | US | disclosed |
| US-7166609-B2 | Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-01-23 | — | — | US | disclosed |
| WO-2004041788-A1 | NOVEL PYRIMIDINE-4,6-DICARBOXAMIDES FOR THE SELECTIVE INHIBITION OF COLLAGENASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-05-21 | — | — | WO | disclosed |