Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 3/20 | 0.32 |
| ▸ | HTR7 | P34969 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4722801 | 0.85 | HTR7 (0.40) | MAPTRAB9ASMN1; SMN2NPC1NISCH | |
| SCHEMBL4765802 | 0.80 | ALOX15 (0.37) | MAPTRAB9ASMN1; SMN2NPC1ALOX15 | |
| SCHEMBL4724580 | 0.74 | ITGB2 (0.31) | SIGMAR1 | |
| SCHEMBL3237232 | 0.68 | NISCH (0.46) | MAPTRAB9ASMN1; SMN2NPC1NISCH | |
| Methoxymethane SCHEMBL15104847 | 0.67 | ALDH1A1 (0.50) | MAPTRAB9ASMN1; SMN2NISCHALDH1A1 | |
| SCHEMBL4723665 | 0.66 | NPC1 (0.43) | MAPTRAB9ASMN1; SMN2NPC1SLC6A3 | |
| Fluoride SCHEMBL28238612 | 0.64 | ALDH1A1 (0.56) | MAPTSMN1; SMN2NISCHALDH1A1HPGD | |
| SCHEMBL27582162 | 0.63 | HTR7 (0.40) | MAPTRAB9ASMN1; SMN2NPC1NISCH | |
| SCHEMBL25302086 | 0.62 | ALDH1A1 (0.59) | MAPTSMN1; SMN2NISCHALDH1A1HPGD | |
| SCHEMBL29350007 | 0.62 | ALDH1A1 (0.59) | MAPTSMN1; SMN2NISCHALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874780-A1 | 4-PIPERAZINYLTHIENO[2,3-D]PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | Pharmacia & Upjohn Company LLC (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006100591-A1 | 4-PIPERAZINNYLTHIENO [2,3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-09-28 | — | — | WO | disclosed |