Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 7/20 | 0.72 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.66 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.60 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.60 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.60 |
| ▸ | GCGR | P47871 | 1/20 | 0.60 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.54 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.54 |
| ▸ | TEK | Q02763 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4490139 | 0.81 | RAF1 (0.69) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL17002180 | 0.80 | MAPK14 (1.00) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4552086 | 0.79 | RAF1 (0.88) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL30762099 | 0.79 | RAF1 (0.76) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL31742329 | 0.79 | RAF1 (0.76) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4467742 | 0.77 | RAF1 (0.64) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2649978 | 0.75 | MAPK14 (1.00) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL12180841 | 0.74 | RAF1 (0.68) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL8797140 | 0.74 | RAF1 (0.67) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4472619 | 0.74 | NOX1 (0.53) | RAF1MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670780-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-12-17 | — | — | EP | disclosed |
| EP-1670780-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005030151-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (US) | 2005-04-07 | — | — | WO | disclosed |