Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.67 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.66 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.66 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.66 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.66 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.66 |
| ▸ | GCGR | P47871 | 1/20 | 0.66 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.64 |
| ▸ | IDO1 | P14902 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.54 |
| ▸ | GLA | P06280 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31742329 | 0.95 | RAF1 (0.76) | RAF1ALOX5MAPK14MAPK13MAPK12 | |
| SCHEMBL30762099 | 0.95 | RAF1 (0.76) | RAF1ALOX5MAPK14MAPK13MAPK12 | |
| SCHEMBL8797410 | 0.86 | NOX1 (0.72) | RAF1ALOX5MAPK14MAPK13MAPK12 | |
| SCHEMBL4552086 | 0.86 | RAF1 (0.88) | RAF1ALOX5MAPK14MAPK13MAPK12 | |
| SCHEMBL19868984 | 0.81 | MAPK14 (0.81) | RAF1ALOX5MAPK14MAPK13MAPK12 | |
| SCHEMBL6467424 | 0.80 | NOX1 (0.72) | RAF1ALOX5MAPK14MAPK13MAPK12 | |
| SCHEMBL8032578 | 0.80 | NOX1 (0.76) | RAF1ALOX5MAPK14MAPK13MAPK12 | |
| SCHEMBL2649978 | 0.80 | MAPK14 (1.00) | RAF1ALOX5MAPK14MAPK13MAPK12 | |
| SCHEMBL1071183 | 0.78 | NOX1 (1.00) | RAF1ALOX5MAPK14MAPK13MAPK12 | |
| SCHEMBL21026201 | 0.78 | ALDH1A1 (0.66) | KDM4EALDH1A1HPGDGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812829-A1 | Substituted imidazoles as modulators of multi-drug resistance | ONTOGEN CORPORATION (US) | 1997-12-17 | — | — | EP | disclosed |