Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.68 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | GLA | P06280 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | IDO1 | P14902 | 1/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | GCGR | P47871 | 1/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15071001 | 0.96 | MAPK14 (0.63) | RAF1MAPK14KDM4EALDH1A1HPGD | |
| SCHEMBL15071002 | 0.88 | KDM4E (0.67) | RAF1MAPK14KDM4EALDH1A1HPGD | |
| SCHEMBL15050028 | 0.88 | KDM4E (0.67) | RAF1MAPK14KDM4EALDH1A1HPGD | |
| SCHEMBL4552086 | 0.86 | RAF1 (0.88) | RAF1MAPK14KDM4EALDH1A1HPGD | |
| SCHEMBL2594783 | 0.81 | KDM4E (0.63) | RAF1MAPK14KDM4EALDH1A1HPGD | |
| SCHEMBL30762099 | 0.79 | RAF1 (0.76) | RAF1MAPK14KDM4EALDH1A1HPGD | |
| SCHEMBL31742329 | 0.79 | RAF1 (0.76) | RAF1MAPK14KDM4EALDH1A1HPGD | |
| SCHEMBL17002180 | 0.77 | MAPK14 (1.00) | RAF1MAPK14MAPK13ALOX5GCGR | |
| SCHEMBL4721236 | 0.74 | RAF1 (0.72) | RAF1MAPK14KDM4EALDH1A1HPGD | |
| SCHEMBL8797140 | 0.74 | RAF1 (0.67) | RAF1MAPK14KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165489-A1 | Small Molecule Modulators of HIV-1 Capsid Stability and Methods Thereof | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-06-27 | — | — | US | disclosed |
| WO-2011139637-A1 | SMALL-MOLECULE MODULATORS OF HIV-1 CAPSID STABILITY AND METHODS THEREOF | PHILADELPHIA HEALTH & EDUCATION CORPORATION (US) | 2011-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165489-A1 | Small Molecule Modulators of HIV-1 Capsid Stability and Methods Thereof | ZC3HAV1, MAVS, HAVCR2 | RAF1 3537/4885MAPK14 3222/4885KDM4E 1542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.