Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 11/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 9/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 9/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4720430 | 0.94 | CYP19A1 (0.53) | CYP19A1CYP2D6CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL4723818 | 0.87 | NPC1 (0.50) | CYP19A1CYP2D6CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL27607389 | 0.79 | HSD11B1 (0.46) | RAB9ANPC1MAPTKDM4EALDH1A1 | |
| SCHEMBL4723625 | 0.78 | ENPP3 (0.50) | RAB9ANPC1MAPTKDM4EALDH1A1 | |
| SCHEMBL28271180 | 0.76 | ENPP3 (0.31) | — | |
| SCHEMBL5583851 | 0.74 | CYP2D6 (0.76) | CYP19A1CYP2D6CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL9151170 | 0.74 | CYP2D6 (0.76) | CYP19A1CYP2D6CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL4724249 | 0.72 | CYP19A1 (0.56) | CYP19A1CYP2D6CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL15060978 | 0.72 | CYP2D6 (0.57) | CYP19A1CYP2D6CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL4922573 | 0.72 | CYP19A1 (0.39) | CYP19A1CYP2D6CYP2C9CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080176857-A1 | 4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors | PFIZER INC. | 2008-07-24 | — | — | US | disclosed |
| EP-1874780-A1 | 4-PIPERAZINYLTHIENO[2,3-D]PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | Pharmacia & Upjohn Company LLC (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006100591-A1 | 4-PIPERAZINNYLTHIENO [2,3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176857-A1 | 4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors | TBXA2R, P2RY4, PF4 | CYP19A1 1796/4885CYP2D6 112/4885CYP2C9 303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.