Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1406926 | 0.88 | LMNA (0.46) | LMNANPC1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL1406998 | 0.84 | ALDH1A1 (0.49) | LMNANPC1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4716749 | 0.82 | AGTR1 (0.41) | PDE4B | |
| SCHEMBL1406834 | 0.82 | NPC1 (0.49) | LMNANPC1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL9312267 | 0.81 | KMT2A (0.52) | LMNANPC1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL1407215 | 0.80 | ALDH1A1 (0.46) | LMNANPC1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4719726 | 0.80 | LMNA (0.43) | LMNANPC1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4717605 | 0.80 | KDM4E (0.47) | LMNANPC1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL12559490 | 0.79 | ALDH1A1 (0.54) | LMNANPC1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL26135042 | 0.79 | NPC1 (0.48) | LMNANPC1ALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999114-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. Hoffmann-la Roche AG (CH) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007107470-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | WO | disclosed |