Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4721914 | 0.94 | GPR119 (0.46) | GPR119TBK1S1PR1 | |
| SCHEMBL4721883 | 0.92 | CDK1 (0.40) | GPR119TBK1S1PR1CDK1CDK2 | |
| SCHEMBL4719878 | 0.91 | TNNI3K (0.41) | GPR119TBK1S1PR1LIMK2 | |
| SCHEMBL4722994 | 0.91 | GPR119 (0.39) | GPR119TBK1S1PR1JAK1JAK2 | |
| SCHEMBL4720626 | 0.90 | S1PR1 (0.42) | GPR119TBK1S1PR1LIMK2CYP3A4 | |
| SCHEMBL385723 | 0.89 | GPR119 (0.51) | GPR119TBK1JAK1JAK2LIMK2 | |
| SCHEMBL4723270 | 0.89 | LCK (0.40) | GPR119JAK1JAK2KDM4EL3MBTL1 | |
| SCHEMBL4718690 | 0.87 | TBK1 (0.38) | GPR119TBK1S1PR1CYP3A4CYP2C9 | |
| SCHEMBL27939280 | 0.86 | GPR119 (0.44) | GPR119TBK1S1PR1CYP3A4CYP2C9 | |
| SCHEMBL4723148 | 0.86 | GPR119 (0.41) | GPR119TBK1S1PR1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |