Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.36 |
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4721914 | 0.91 | GPR119 (0.46) | GPR119TBK1S1PR1 | |
| SCHEMBL386560 | 0.89 | GPR119 (0.52) | GPR119TBK1CYP3A4 | |
| SCHEMBL4719368 | 0.88 | TBK1 (0.38) | GPR119TBK1S1PR1ACACBSYK | |
| SCHEMBL4722459 | 0.88 | TBK1 (0.38) | GPR119TBK1S1PR1ACACBSYK | |
| SCHEMBL4721660 | 0.86 | GPR119 (0.40) | GPR119TBK1S1PR1ACACBFGFR3 | |
| SCHEMBL4721883 | 0.86 | CDK1 (0.40) | GPR119TBK1S1PR1ACACBFGFR3 | |
| SCHEMBL4718690 | 0.85 | TBK1 (0.38) | GPR119TBK1S1PR1ACACBFGFR3 | |
| SCHEMBL4719878 | 0.85 | TNNI3K (0.41) | GPR119TBK1S1PR1 | |
| SCHEMBL4722994 | 0.85 | GPR119 (0.39) | GPR119TBK1S1PR1ACACBFGFR3 | |
| SCHEMBL4719783 | 0.84 | TBK1 (0.39) | GPR119TBK1S1PR1ACACBFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |