Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | BACE1 | P56817 | 3/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718673 | 0.84 | KMT2A (0.72) | ALDH1A1KMT2AMEN1GAAGPBAR1 | |
| Hydrochloric Acid SCHEMBL30684627 | 0.83 | KMT2A (0.70) | ALDH1A1KMT2AMEN1GAAGPBAR1 | |
| SCHEMBL27913634 | 0.81 | GPBAR1 (0.60) | ALDH1A1KMT2AMEN1GAAGPBAR1 | |
| SCHEMBL457706 | 0.79 | GPBAR1 (0.59) | ALDH1A1KMT2AMEN1GAAGPBAR1 | |
| SCHEMBL2475844 | 0.79 | GPBAR1 (0.59) | ALDH1A1KMT2AMEN1GAAGPBAR1 | |
| SCHEMBL3068021 | 0.78 | GPBAR1 (0.61) | ALDH1A1KMT2AMEN1GAAGPBAR1 | |
| Hydrochloric Acid SCHEMBL3981907 | 0.78 | GPBAR1 (0.57) | ALDH1A1KMT2AMEN1GAAGPBAR1 | |
| SCHEMBL4721200 | 0.76 | LMNA (0.72) | ALDH1A1KMT2AMEN1GAAGPBAR1 | |
| SCHEMBL8408128 | 0.76 | ALDH1A1 (0.60) | ALDH1A1KMT2AMEN1GAAGPBAR1 | |
| SCHEMBL2471701 | 0.75 | GPBAR1 (0.54) | ALDH1A1KMT2AMEN1GAAGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871770-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | Kalypsys, Inc. (US) | 2008-01-02 | — | — | EP | disclosed |
| US-20060252807-A1 | Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders | KALYPSYS, INC. | 2006-11-09 | — | — | US | disclosed |
| WO-2006116355-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | KALYPSYS, INC. (US) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252807-A1 | Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders | MAPK1, MAP3K1, MAPK4 | ALDH1A1 4346/4885L3MBTL1 1343/4885KMT2A 3283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.