Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.47 |
| ▸ | BRAF | P15056 | 3/20 | 0.42 |
| ▸ | WNT1 | P04628 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.42 |
| ▸ | RAF1 | P04049 | 2/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.39 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | RHOA | P61586 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL389260 | 0.89 | GPR119 (0.53) | EGFRERBB2BRAFWNT1GSK3B | |
| SCHEMBL5603499 | 0.84 | EGFR (0.54) | EGFRERBB2BRAFWNT1GSK3B | |
| SCHEMBL4723272 | 0.83 | GPR119 (0.46) | GPR119 | |
| SCHEMBL4723387 | 0.81 | GPR119 (0.49) | GPR119 | |
| SCHEMBL4721070 | 0.80 | KDR (0.49) | GPR119 | |
| SCHEMBL4723183 | 0.78 | GPR119 (0.46) | EGFRDYRK1AGPR119 | |
| SCHEMBL4721907 | 0.78 | GPR119 (0.47) | GPR119 | |
| SCHEMBL4722122 | 0.78 | GPR119 (0.51) | GPR119 | |
| SCHEMBL4723224 | 0.78 | GPR119 (0.46) | GPR119 | |
| SCHEMBL4722319 | 0.78 | GPR119 (0.43) | ERBB2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |